Gene name:
Map1b (Mtap1b;Mtap5) ;
Protein name:
Microtubule-associated protein 1B (MAP-1B) ;
Alternative:
MAP1.2 ;MAP1(X) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins. LC1 interacts with the amino-terminal region of MAP1B. Interacts with ANP32A and TIAM2. Interacts (via C-terminus) with GAN (via Kelch domains).
Function:
The function of brain MAPS is essentially unknown. Phosphorylated MAP1B may play a role in the cytoskeletal changes that accompany neurite extension. Possibly MAP1B Binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules.
Subcellular Location:
Cytoplasm
cytoskeleton
Protein Attributes:
50:
MATVVVEATE | PEPSGSIGNP | AASTSPSLSH | RFLDSKFYLL | VVVGETVTEE |
100:
HLRRAIGNIE | LGIRSWDTNL | IECNLDQELK | LFVSRHSARF | SPEVPGQKIL |
150:
HHRSDVLETV | VLINPSDEAV | STEVRLMITD | AARHKLLVLT | GQCFENTGEL |
200:
ILQSGSFSFQ | NFIEIFTDQE | IGELLSTTHP | ANKASLTLFC | PEEGDWKNSN |
250:
LDRHNLQDFI | NIKLNSASIL | PEMEGLSEFT | EYLSESVEVP | SPFDILEPPT |
300:
SGGFLKLSKP | CCYIFPGGRG | DSALFAVNGF | NMLINGGSER | KSCFWKLIRH |
350:
LDRVDSILLT | HIGDDNLPGI | NSMLQRKIAE | LEEERSQGST | SNSDWMKNLI |
400:
SPDLGVVFLN | VPENLKDPEP | NIKMKRSIEE | ACFTLQYLNK | LSMKPEPLFR |
450:
SVGNTIEPVI | LFQKMGVGKL | EMYVLNPVKS | SKEMQYFMQQ | WTGTNKDKAE |
500:
LILPNGQEVD | IPISYLTSVS | SLIVWHPANP | AEKIIRVLFP | GNSTQYNILE |
550:
GLEKLKHLDF | LKQPLATQKD | LTGQVPTPPV | KQVKLKQRAD | SRESLKPATK |
600:
PVASKSVRKE | SKEETPEVTK | TSQVEKTPKV | ESKEKVLVKK | DKPVKTESKP |
650:
SVTEKEVSSK | EEQSPVKAEV | AEKQATESKP | KVTKDKVVKK | EIKTKLEEKK |
700:
EEKPKKEVVK | KEDKTPLKKD | EKPRKEEVKK | EIKKEIKKEE | RKELKKEVKK |
750:
ETPLKDAKKE | VKKEEKKEVK | KEEKEPKKEI | KKISKDIKKS | TPLSDTKKPS |
800:
ALKPKVAKKE | ESTKKEPLAA | GKLKDKGKVK | VIKKEGKTTE | AAATAVGTAA |
850:
TTAAVVAAAG | IAASGPVKEL | EAERSLMSSP | EDLTKDFEEL | KAEEIDVAKD |
900:
IKPQLELIED | EEKLKETQPG | EAYVIQKETE | VSKGSAESPD | EGITTTEGEG |
950:
ECEQTPEELE | PVEKQGVDDI | EKFEDEGAGF | EESSETGDYE | EKAETEEAEE |
1000:
PEEDGEDNAS | GSASKHSPTE | DDESAKAEAD | VHLKEKRESV | VSGDDRAEED |
1050:
MDDVLEKGEA | EQSEEEGEEE | DKAEDAREEG | YEPDKTEAED | YVMAVADKAA |
1100:
EAGVTEEQYG | YLGTSAKQPG | IQSPSREPAS | SIHDETLPGG | SESEATASDE |
1150:
ENREDQPEEF | TATSGYTQST | IEISSEPTPM | DEMSTPRDVM | SDETNNEETE |
1200:
SPSQEFVNIT | KYESSLYSQE | YSKPAVASFN | GLSEGSKTDA | TDGKDYNASA |
1250:
STISPPSSME | EDKFSKSALR | DAYCSEEKEL | KASAELDIKD | VSDERLSPAK |
1300:
SPSLSPSPPS | PIEKTPLGER | SVNFSLTPNE | IKVSAEGEAR | SVSPGVTQAV |
1350:
VEEHCASPEE | KTLEVVSPSQ | SVTGSAGHTP | YYQSPTDEKS | SHLPTEVTEK |
1400:
PQAVPVSFEF | SEAKDENERA | SLSPMDEPVP | DSESPVEKVL | SPLRSPPLLG |
1450:
SESPYEDFLS | ADSKVLGRRS | ESPFEGKNGK | QGFPDRESPV | SDLTSTGLYQ |
1500:
DKQEEKSTGF | IPIKEDFGPE | KKTSDVETMS | SQSALALDER | KLGGDVSPTQ |
1550:
IDVSQFGSFK | EDTKMSISEG | TVSDKSATPV | DEGVAEDTYS | HMEGVASVST |
1600:
ASVATSSFPE | PTTDDVSPSL | HAEVGSPHST | EVDDSLSVSV | VQTPTTFQET |
1650:
EMSPSKEECP | RPMSISPPDF | SPKTAKSRTP | VQDHRSEQSS | MSIEFGQESP |
1700:
EHSLAMDFSR | QSPDHPTLGA | SVLHITENGP | TEVDYSPSDI | QDSSLSHKIP |
1750:
PTEEPSYTQD | NDLSELISVS | QVEASPSTSS | AHTPSQIASP | LQEDTLSDVV |
1800:
PPREMSLYAS | LASEKVQSLE | GEKLSPKSDI | SPLTPRESSP | LYSPGFSDST |
1850:
SAAKETAAAH | QASSSPPIDA | ATAEPYGFRS | SMLFDTMQHH | LALNRDLTTS |
1900:
SVEKDSGGKT | PGDFNYAYQK | PENAAGSPDE | EDYDYESQEK | TIRTHDVGGY |
1950:
YYEKTERTIK | SPCDSGYSYE | TIEKTIKTPE | DGGYTCEITE | KTTRTPEEGG |
2000:
YSYEISEKTT | RTPEVSGYTY | EKTERSRRLL | DDISNGYDDT | EDGGHTLGDC |
2050:
SYSYETTEKI | TSFPESESYS | YETSTKTTRS | PDTSAYCYET | MEKITKTPQA |
2100:
STYSYETSDR | CYTTEKKSPS | EARQDVDLCL | VSSCEFKHPK | TELSPSFINP |
2150:
NPLEWFAGEE | PTEESEKPLT | QSGGAPPPSG | GKQQGRQCDE | TPPTSVSESA |
2200:
PSQTDSDVPP | ETEECPSITA | DANIDSEDES | ETIPTDKTVT | YKHMDPPPAP |
2250:
MQDRSPSPRH | PDVSMVDPDA | LAVDQNLGKA | LKKDLKEKTK | TKKPGTKTKS |
2300:
SSPVKKGDGK | SKPLAASPKP | GALKESSDKV | SRVASPKKKE | SVEKATKTTT |
2350:
TPEVKATRGE | EKDKETKNAA | NASASKSAKT | ATAGPGTTKT | AKSSTVPPGL |
2400:
PVYLDLCYIP | NHSNSKNVDV | EFFKRVRSSY | YVVSGNDPAA | EEPSRAVLDA |
2450:
LLEGKAQWGS | NMQVTLIPTH | DSEVMREWYQ | ETHEKQQDLN | IMVLASSSTV |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
ELISA Kit for Mouse MAP-1B
ELISA Kit for Mouse MAP-1B
ELISA Kit for Mouse MAP-1B
CLIA Kit for Mouse MAP-1B
CLIA Kit for Mouse MAP-1B
CLIA Kit for Mouse MAP-1B
Polyclonal Antibody for Mouse MAP-1B
Polyclonal Antibody for Mouse MAP-1B
Polyclonal Antibody for Mouse MAP-1B
Monoclonal Antibody for Mouse MAP-1B
Monoclonal Antibody for Mouse MAP-1B
Monoclonal Antibody for Mouse MAP-1B
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];DOMAIN
strain :
Swiss Webster .
tissue :
Brain .
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"Lineage-specific biology revealed by a finished genome assembly of the mouse."
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PLoS Biol.7:E1000112-E1000112(2009)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
C57BL/6J .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH GAN
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH ANP32A
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1260; SER-1391 AND SER-1395;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Embryonic brain .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-541; SER-544; SER-561; SER-989; SER-1013; SER-1307; SER-1438; SER-1775 AND SER-1911;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Brain .
7.
"Rho-kinase modulates the function of STEF, a Rac GEF, through its phosphorylation."
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH TIAM2
8.
"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Brain cortex .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : S-NITROSYLATION AT CYS-2460
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN REGULATION OF ALPHA-TUBULIN TYROSINATION;INTERACTION WITH TTL
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-614; SER-1438; SER-1497 AND SER-1775;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Embryonic fibroblast .
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION